Yes, charitable donations made to qualified 501(c)(3) organizations are deductible. If you're self-employed, you can deduct them on Schedule A (Itemized Deductions) when filing your 1099 tax return. It's important to keep detailed records of your donations, including receipts and acknowledgments from the charity, as the IRS may ask for proof. Additionally, the total amount of your itemized deductions must exceed the standard deduction for you to benefit from these deductions. Always consider consulting a tax professional to ensure you're maximizing your eligible deductions while staying compliant with tax regulations.